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Although these classical inhibitors show great potential in preclinical research, their clinical translation still faces substantial obstacles, including poor metabolic stability, suboptimal pharmacokinetics, and the critical fact that no anti-ferroptosis drug has yet entered human trials

Preliminary results on 30 patients showed a 42% improvement in the ECCA scarring score after three sessions of microneedling combined with GHK-Cu + PRP, versus 28% with PRP alone

Stimulation of hair follicles In studies on hair follicles GHK-Cu: Prolongs the anagen phase (the active growth phase) Stimulates dermal papilla cells (the control center of the follicle) Increases blood supply to follicles (via angiogenesis) This is the research basis for AHK-Cu (an analogous copper tripeptide optimized for hair) and for cosmetic formulations against hair loss

*Correspondence: Jianhua Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

from Cornell University, and graduated magna cum laude degree from the Ottawa University School of Medicine